Wikipedia

AZ10419369

AZ10419369
Clinical data
Other namesAZ-10419369
Drug classSerotonin 5-HT1B receptor agonist
ATC code
  • None
Identifiers
  • 5-methyl-8-(4-methylpiperazin-1-yl)-N-(4-morpholin-4-ylphenyl)-4-oxochromene-2-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
UNII
ChEMBL
Chemical and physical data
FormulaC26H30N4O4
Molar mass462.550 g·mol−1
3D model (JSmol)
  • CC1=C2C(=O)C=C(OC2=C(C=C1)N3CCN(CC3)C)C(=O)NC4=CC=C(C=C4)N5CCOCC5
  • InChI=1S/C26H30N4O4/c1-18-3-8-21(30-11-9-28(2)10-12-30)25-24(18)22(31)17-23(34-25)26(32)27-19-4-6-20(7-5-19)29-13-15-33-16-14-29/h3-8,17H,9-16H2,1-2H3,(H,27,32)
  • Key:JKPWOPNZKYPRPZ-UHFFFAOYSA-N

AZ10419369 is a potent and selective serotonin 5-HT1B receptor agonist (Ki = 0.8 nM) which is used in scientific research.[1][2][3] A radiolabeled form, [11C]-AZ10419369, is one of two serotonin 5-HT1B receptor ligands used in positron emission tomography (PET) imaging, including in both animal and human studies.[1][2][3] AZ10419369 was first described in the scientific literature by 2008.[3]

References

[edit]
  1. ^ a b Tiger M, Varnäs K, Okubo Y, Lundberg J (May 2018). "The 5-HT1B receptor - a potential target for antidepressant treatment". Psychopharmacology. 235 (5): 1317–1334. doi:10.1007/s00213-018-4872-1. PMC 5919989. PMID 29546551.
  2. ^ a b Kumar JS, Mann JJ (2014). "PET tracers for serotonin receptors and their applications". Central Nervous System Agents in Medicinal Chemistry. 14 (2): 96–112. doi:10.2174/1871524914666141030124316. PMC 4330993. PMID 25360773.
  3. ^ a b c Pierson ME, Andersson J, Nyberg S, McCarthy DJ, Finnema SJ, Varnäs K, et al. (July 2008). "[11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain". NeuroImage. 41 (3): 1075–1085. doi:10.1016/j.neuroimage.2008.02.063. PMID 18434202.
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