EPH receptor B1

EPHB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DJS, 2EAO, 3ZFX
Identifiers
Aliases	EPHB1, Ephb1, 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net, EPHT2, EPH receptor B1, ELK, NET
External IDs	OMIM: 600600; MGI: 1096337; HomoloGene: 20936; GeneCards: EPHB1; OMA:EPHB1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	135,260,467 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	102,231,892 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; Brodmann area 23; ; secondary oocyte; ; cerebellum; ; cerebellar cortex; ; ventricular zone; ; cerebellar hemisphere; ; primary visual cortex; ; right hemisphere of cerebellum;
	Top expressed in
	otic vesicle; ; lumbar subsegment of spinal cord; ; otolith organ; ; utricle; ; inferior colliculi; ; substantia nigra; ; deep cerebellar nuclei; ; superior colliculus; ; Rostral migratory stream; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; axon guidance receptor activity; transmembrane-ephrin receptor activity; protein-containing complex binding;
Cellular component	integral component of membrane; endosome; cell projection; early endosome membrane; membrane; integral component of plasma membrane; extracellular region; dendrite; extracellular exosome; endoplasmic reticulum; cytosol; plasma membrane; axon; cytoplasm; filopodium tip; membrane raft; neuron projection; receptor complex; glutamatergic synapse;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; dendritic spine development; cell-substrate adhesion; regulation of JNK cascade; protein phosphorylation; cell adhesion; regulation of neuron death; regulation of ERK1 and ERK2 cascade; protein autophosphorylation; peptidyl-tyrosine phosphorylation; immunological synapse formation; axon guidance; optic nerve morphogenesis; central nervous system projection neuron axonogenesis; retinal ganglion cell axon guidance; ephrin receptor signaling pathway; camera-type eye morphogenesis; positive regulation of synapse assembly; dendritic spine morphogenesis; angiogenesis; skeletal muscle satellite cell activation; cranial nerve development; neurogenesis; establishment of cell polarity; detection of temperature stimulus involved in sensory perception of pain; cell chemotaxis; neural precursor cell proliferation; negative regulation of skeletal muscle satellite cell proliferation; negative regulation of satellite cell differentiation; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2047
	270190
	ENSG00000154928
	ENSMUSG00000032537
	P54762
	Q8CBF3
	NM_004441
	NM_001168296; NM_173447
	NP_004432
	NP_001161768; NP_775623
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.^[5]^[6]

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[6]

Interactions

EPH receptor B1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154928 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032537 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, et al. (September 1995). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain". Genomics. 29 (2): 426–437. doi:10.1006/geno.1995.9985. PMID 8666391.
^ ^a ^b "Entrez Gene: EPHB1 EPH receptor B1".
^ Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, et al. (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes & Development. 12 (5): 667–678. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.
^ Han DC, Shen TL, Miao H, Wang B, Guan JL (November 2002). "EphB1 associates with Grb7 and regulates cell migration". The Journal of Biological Chemistry. 277 (47): 45655–45661. doi:10.1074/jbc.M203165200. PMID 12223469.
^ Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (January 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". The Journal of Biological Chemistry. 273 (3): 1303–1308. doi:10.1074/jbc.273.3.1303. PMID 9430661.
^ Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, et al. (September 2003). "Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm". Neuron. 39 (6): 919–935. doi:10.1016/j.neuron.2003.08.017. PMID 12971893. S2CID 18565204.

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annual Review of Neuroscience. 21: 309–345. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (March 1998). "The Eph family receptors and ligands". Pharmacology & Therapeutics. 77 (3): 151–181. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Abrahamson DR, Robert B, Hyink DP, St John PL, Daniel TO (September 1998). "Origins and formation of microvasculature in the developing kidney". Kidney International. Supplement. 67: S7–11. doi:10.1046/j.1523-1755.1998.06702.x. PMID 9736245.
Holder N, Klein R (May 1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–2044. doi:10.1242/dev.126.10.2033. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: Regulators of guidance and assembly". A Survey of Cell Biology. International Review of Cytology. Vol. 196. pp. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (July 2000). "Roles of Eph receptors and ephrins in segmental patterning". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Wilkinson DG (March 2001). "Multiple roles of EPH receptors and ephrins in neural development". Nature Reviews. Neuroscience. 2 (3): 155–164. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
Larose L, Gish G, Shoelson S, Pawson T (September 1993). "Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1". Oncogene. 8 (9): 2493–2499. PMID 7689724.
Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, et al. (November 1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–819. Bibcode:1994Sci...266..816D. doi:10.1126/science.7973638. PMID 7973638.
Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, et al. (August 1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors". The EMBO Journal. 13 (16): 3757–3762. doi:10.1002/j.1460-2075.1994.tb06685.x. PMC 395287. PMID 8070404.
Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, et al. (November 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Molecular Immunology. 32 (16): 1197–1205. doi:10.1016/0161-5890(95)00108-5. PMID 8559144.
Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, et al. (July 1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
Stein E, Cerretti DP, Daniel TO (September 1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells". The Journal of Biological Chemistry. 271 (38): 23588–23593. doi:10.1074/jbc.271.38.23588. PMID 8798570.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (August 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine. 9 (8): 540–549. doi:10.1006/cyto.1997.0199. PMID 9245480.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–404. August 1997. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (January 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". The Journal of Biological Chemistry. 273 (3): 1303–1308. doi:10.1074/jbc.273.3.1303. PMID 9430661.
Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, et al. (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes & Development. 12 (5): 667–678. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154928 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032537 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Tang_1995-5] Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, et al. (September 1995). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain". Genomics. 29 (2): 426–437. doi:10.1006/geno.1995.9985. PMID 8666391.

[entrez-6] "Entrez Gene: EPHB1 EPH receptor B1".

[Stein_1998-7] Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, et al. (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes & Development. 12 (5): 667–678. doi:10.1101/gad.12.5.667. PMC 316584. PMID 9499402.

[Han_2002-8] Han DC, Shen TL, Miao H, Wang B, Guan JL (November 2002). "EphB1 associates with Grb7 and regulates cell migration". The Journal of Biological Chemistry. 277 (47): 45655–45661. doi:10.1074/jbc.M203165200. PMID 12223469.

[Stein_1998a-9] Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO (January 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". The Journal of Biological Chemistry. 273 (3): 1303–1308. doi:10.1074/jbc.273.3.1303. PMID 9430661.

[10] Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, et al. (September 2003). "Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm". Neuron. 39 (6): 919–935. doi:10.1016/j.neuron.2003.08.017. PMID 12971893. S2CID 18565204.

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EPH receptor B1

Function

Interactions

References

Further reading