G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene.[5][6] It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.[7][8][9][10]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000143147 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040836 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Small KM, Seman CA, Castator A, Brown KM, Liggett SB (Apr 2002). "False positive non-synonymous polymorphisms of G-protein coupled receptor genes". FEBS Letters. 516 (1–3): 253–256. Bibcode:2002FEBSL.516..253S. doi:10.1016/S0014-5793(02)02564-4. PMID 11959142. S2CID 35944696.
- ^ "Entrez Gene: GPR161 G protein-coupled receptor 161".
- ^ Tschaikner P, Enzler F, Torres-Quesada O, Aanstad P, Stefan E (2020). "Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium". Cells. 9 (1): 118. doi:10.3390/cells9010118. PMC 7017137. PMID 31947770.
- ^ Patel K, Smith NJ (2024). "Primary cilia, A-kinase anchoring proteins and constitutive activity at the orphan G protein-coupled receptor GPR161: A tale about a tail". British Journal of Pharmacology. 181 (14): 2182–2196. doi:10.1111/bph.16053. PMID 36772847.
- ^ Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, et al. (2024). "GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway". Nature Structural & Molecular Biology. 31 (4): 667–677. doi:10.1038/s41594-024-01223-8. PMC 11221913. PMID 38326651.
- ^ Paillard T, Allam A, Doulazmi M, Hautefeuille M, Fouquet C, Sarde L, et al. (2025). "GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration". Science Advances. 11 (31) eadx3846: eadx3846. doi:10.1126/sciadv.adx3846. PMC 12309678. PMID 40737401.
Further reading
[edit]- Schöneberg T, Schulz A, Gudermann T (2002). "The structural basis of G-protein-coupled receptor function and dysfunction in human diseases". Reviews of Physiology, Biochemistry and Pharmacology. Vol. 144. pp. 143–227. doi:10.1007/BFb0116587. ISBN 978-3-540-42814-5. PMID 11987825.
- Raming K, Konzelmann S, Breer H (1999). "Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone". Receptors & Channels. 6 (2): 141–151. PMID 9932290.
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