Protein-coding gene in humans
Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene .[ 5]
Agonists Antagonists N-acyl derivatives of LysoPS act as antagonists at GPR174.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GPR174 G protein-coupled receptor 174" .^ Liu G LX (Dec 2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174" . PLOS Biology . 21 (12): e3002387. doi :10.1371/journal.pbio.3002387 PMC 10721165 PMID 38048360 . ^ Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, et al. (Sep 2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling" . Nature Communications . 14 (1) 5901. doi :10.1038/s41467-023-41654-3 . PMC 10516915 PMID 37737235 . ^ Sayama M, Uwamizu A, Ikubo M, Chen L, Yan G, Otani Y, et al. (July 2021). "Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine". Journal of Medicinal Chemistry . 64 (14): 10059– 10101. doi :10.1021/acs.jmedchem.1c00347 . PMID 34233115 .
