Imidazolylindoles are a group of cyclized tryptamines in which the amine has been cyclized into an imidazoline ring. They include AGH-107, AGH-192, and AH-494. These compounds are known to act as selective serotonin 5-HT7 receptor agonists.[1][2][3]
See also
[edit]References
[edit]- ^ Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ (November 2018). "Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists". Medchemcomm. 9 (11): 1882–1890. doi:10.1039/c8md00313k. PMC 6256855. PMID 30568756.
- ^ Jakubowska K, Hogendorf AS, Gołda S, Jantas D (August 2024). "Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT7 Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells". Neurochem Res. 49 (8): 2179–2196. doi:10.1007/s11064-024-04159-z. PMC 11233329. PMID 38834845.
- ^ Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (May 2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". Eur J Med Chem. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783.
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