Protein-coding gene in the species Homo sapiens
Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene .[ 5] [ 6] [ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000183785 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030137 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, et al. (April 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochemical and Biophysical Research Communications . 270 (3): 1111– 1118. Bibcode :2000BBRC..270.1111S . doi :10.1006/bbrc.2000.2571 . PMID 10772959 .
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489– 495. Bibcode :1999Natur.402..489D . doi :10.1038/990031 . PMID 10591208 .
^ "Entrez Gene: TUBA8 tubulin, alpha 8" .
^ "GeneCards: TUBA8 gene" .
Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, et al. (September 1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro" . Molecular and Cellular Biology . 15 (9): 5188– 5195. doi :10.1128/MCB.15.9.5188 . PMC 230766 . PMID 7651436 .
Feierbach B, Nogales E, Downing KH, Stearns T (January 1999). "Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin" . The Journal of Cell Biology . 144 (1): 113– 124. doi :10.1083/jcb.144.1.113 . PMC 2148126 . PMID 9885248 .
Herreros L, Rodríguez-Fernandez JL, Brown MC, Alonso-Lebrero JL, Cabañas C, Sánchez-Madrid F, et al. (August 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton" . The Journal of Biological Chemistry . 275 (34): 26436– 26440. doi :10.1074/jbc.M003970200 . hdl :10261/135387 . PMID 10840040 .
Watts NR, Sackett DL, Ward RD, Miller MW, Wingfield PT, Stahl SS, et al. (July 2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings" . The Journal of Cell Biology . 150 (2): 349– 360. doi :10.1083/jcb.150.2.349 . PMC 2180222 . PMID 10908577 .
Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (December 2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis" . Oncogene . 19 (52): 5997– 6006. doi :10.1038/sj.onc.1204002 . PMID 11146551 .
Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ (March 2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin" . Journal of Neurochemistry . 80 (6): 980– 988. doi :10.1046/j.0022-3042.2002.00778.x . PMC 2925652 . PMID 11953448 .
Chen D, Wang M, Zhou S, Zhou Q (December 2002). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim" . The EMBO Journal . 21 (24): 6801– 6810. doi :10.1093/emboj/cdf683 . PMC 139103 . PMID 12486001 .
Xu Y, Kulkosky J, Acheampong E, Nunnari G, Sullivan J, Pomerantz RJ (May 2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy" . Proceedings of the National Academy of Sciences of the United States of America . 101 (18): 7070– 7075. Bibcode :2004PNAS..101.7070X . doi :10.1073/pnas.0304859101 . PMC 406467 . PMID 15103018 .
Campbell GR, Pasquier E, Watkins J, Bourgarel-Rey V, Peyrot V, Esquieu D, et al. (November 2004). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis" . The Journal of Biological Chemistry . 279 (46): 48197– 48204. Bibcode :2004JBiCh.27948197C . doi :10.1074/jbc.M406195200 . PMID 15331610 .
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biology . 5 (10) R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802 .
de Mareuil J, Carre M, Barbier P, Campbell GR, Lancelot S, Opi S, et al. (February 2005). "HIV-1 Tat protein enhances microtubule polymerization" . Retrovirology . 2 5. doi :10.1186/1742-4690-2-5 . PMC 549075 . PMID 15691386 .
Giacca M (February 2005). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?" . Retrovirology . 2 7. doi :10.1186/1742-4690-2-7 . PMC 549042 . PMID 15698476 .
Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, Barrero M, Ursa A, Cabrero JR, et al. (November 2005). "Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection" . Molecular Biology of the Cell . 16 (11): 5445– 5454. doi :10.1091/mbc.E05-04-0354 . PMC 1266439 . PMID 16148047 .
Canani RB, De Marco G, Passariello A, Buccigrossi V, Ruotolo S, Bracale I, et al. (January 2006). "Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells" . AIDS . 20 (1): 5– 10. doi :10.1097/01.aids.0000198088.85572.68 . PMID 16327313 . S2CID 21499158 .
PDB gallery
1tub : TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION
1tvk : The binding mode of epothilone A on a,b-tubulin by electron crystallography
1z2b : Tubulin-colchicine-vinblastine: stathmin-like domain complex