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Văcărești Prison (Romanian: Închisoarea Văcărești, also Penitenciarul Văcărești; known euphemistically as Mandravela) was a penal facility located in the eponymous quarter of southern Bucharest, Romania, and developed around Văcărești Monastery. It originally extended the latter's functions as a jail in the autonomous realm of Wallachia, emerging as a major processing center for political detainees after the Wallachian Revolution of 1848. In 1864, shortly after the Romanian Principality had been established, the monastery was confiscated by the state; it became a leading state prison in 1865. Though its regime was largely permissive and centered on penal reform for common criminals, Văcărești came to be used in isolating opposition politicians—initially from the liberal camp. These functions were enhanced under the Kingdom of Romania. In quick succession, Văcărești hosted groups associated with the Social Democratic Workers' Party and the peasant rioters of 1907. The institution was traditionally scrutinized by critics for its overcrowding, inadequate plumbing, allegations of mistreatment and corruption, as well as its controversial role in pre-trial detention—which left arrestees in close proximity to hardened criminals. Penal labor was used in various ways, including some that provided material benefits to the inmates; the Obregia psychiatric hospital, located in neighboring Berceni, was largely built by convicts.

During World War I, Văcărești was used by both the Romanian state, for detaining spies and anti-war activists, and the Central Powers (which occupied southern Romania in 1916), for punishing seditious socialists. The restored kingdom incarcerated former collaborators with the enemy, including writers Tudor Arghezi and Ioan Slavici (both of whom left ample records of their Văcărești confinement); they were held alongside instigators of the 1918 labor strike, whose leader I. C. Frimu died in confinement. The state went on to incarcerate in Văcărești the adherents of Bolshevism, from the terrorist Max Goldstein to the entire founding membership of the Romanian Communist Party; in 1923, it also used the prison for rounding up far-right revolutionists, including Corneliu Zelea Codreanu (whose Iron Guard traced its origins and political symbolism to prison life in Văcărești). The complex was in the process of being donated to the Romanian Orthodox Church, but the project was shelved, and, during World War II, it was intensively used by Ion Antonescu's dictatorship for rounding up communists, alleged spies, and people tried for economic sabotage, alongside participants in an Iron Guard-led uprising. The compound was damaged by and earthquake in November 1940, and by Allied carpet-bombing in 1944; allegations of misuse and corruption also resurfaced, with claims that prison inspector Alexandru Petrescu was exploiting female inmates and that Guardists were effectively running the prison from the inside.

Following the anti-fascist coup of August 1944, Văcărești continued to hold Guardist prisoners, but alongside figures of the Antonescu regime, and, in growing numbers, liberal critics of the Communist Party. The latter inaugurated a communist regime in late 1947, upon which a large part of the prison system, managed by the former Văcărești inmates Teohari Georgescu and Alexandru Drăghici, was opened up for anti-communists of various hues. Văcărești was used as a transit prison, with its population reaching over 4,000, from a previous 1,000, and a recommended 400. Conditions worsened, but were generally above the level of other jails and camps; its rudimentary hospital was used to gather up inmates with serious diseases, as well as victims of torture—with many of them dying at Văcărești, into the 1960s. Communist leader Gheorghe Gheorghiu-Dej kept a watch on Securitate activities and approved of some minimal improvements in the prisoners' regimen. His reforms were enhanced and accelerated during his embrace of de-Stalinization, eventually leading to a general amnesty of all political prisoners in 1964. Dej's successor, Nicolae Ceaușescu, initially allowed for Văcărești to be used in detaining common criminals, but ordered it evacuated in 1973. The buildings were used by various institutions, or left in a state of disrepair, until being controversially razed, together with the historic church, in the urban systematization of the 1980s. Its grounds became a wildlife area, eventually included in the Văcărești Nature Park.