Wikipedia

2C-T-25

2C-T-25
Clinical data
Other names4-Isobutylthio-2,5-dimethoxyphenethylamine; 4-iBuS-2,5-DMPEA
Routes of
administration		Oral[1]
Drug classSerotonin receptor modulator; Serotonin 5-HT2A receptor agonist
ATC code
  • None
Identifiers
  • 2-[2,5-dimethoxy-4-(2-methylpropylsulfanyl)phenyl]ethanamine
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H23NO2S
Molar mass269.40 g·mol−1
3D model (JSmol)
  • CC(C)CSC1=C(C=C(C(=C1)OC)CCN)OC
  • InChI=1S/C14H23NO2S/c1-10(2)9-18-14-8-12(16-3)11(5-6-15)7-13(14)17-4/h7-8,10H,5-6,9,15H2,1-4H3
  • Key:OEPKQBQEDYEXMC-UHFFFAOYSA-N

2C-T-25, also known as 4-isobutylthio-2,5-dimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and 2C families.[1][2][3][4] It shows affinity for serotonin receptors and other targets and acts as a potency partial agonist of the serotonin 5-HT2A and 5-HT2B receptors.[4] The dose of 2C-T-25 in humans is unknown.[5] Daniel Trachsel reported that 2C-T-25 was inactive at doses of up to 30 mg orally.[1] The drug was first described in the scientific literature by Trachsel in 2003 and was subsequently described further by Trachsel and colleagues in 2013 and 2018.[1][2][3][4]

See also

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References

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  1. ^ a b c d Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. p. 788. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
  2. ^ a b Shulgin A, Manning T, Daley P (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley: Transform Press. ISBN 978-0-9630096-3-0.
  3. ^ a b Trachsel D (2003). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine)" [Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships. Part 2). 4-Thio-Substituted [2-(2,5-Dimethoxyphenyl)ethyl]amines (=2,5-Dimethoxybenzeneethanamines)]. Helvetica Chimica Acta. 86 (7): 2610–2619. doi:10.1002/hlca.200390210. ISSN 0018-019X.
  4. ^ a b c Luethi D, Trachsel D, Hoener MC, Liechti ME (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)". Neuropharmacology. 134 (Pt A): 141–148. doi:10.1016/j.neuropharm.2017.07.012. PMID 28720478.
  5. ^ Luethi D, Liechti ME (October 2018). "Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics". The International Journal of Neuropsychopharmacology. 21 (10): 926–931. doi:10.1093/ijnp/pyy047. PMC 6165951. PMID 29850881.
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