Wikipedia

HOT-x

HOT-2, a psychedelic drug of the HOT-x group.[1][2]

HOT-x, also known as 4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines or hydroxylated 2C-T derivatives, are a group of psychedelic drugs of the phenethylamine and 2C families.[1][2] They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring.[1][2] The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs.[1][2]

The HOT-x drugs were synthesized and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1][2]

Use and effects

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Oral doses and durations of HOT-x drugs
Compound Chemical name Dose Duration
HOT-2 (N-hydroxy-2C-T-2) N-Hydroxy-4-ethylthio-2,5-dimethoxyphenethylamine 10–18 mg 6–10 hours
HOT-7 (N-hydroxy-2C-T-7) N-Hydroxy-4-propylthio-2,5-dimethoxyphenethylamine 15–25 mg 6–8 hours
HOT-17 (N-hydroxy-2C-T-17) N-Hydroxy-4-sec-butylthio-2,5-dimethoxyphenethylamine 70–120 mg 12–18 hours
Refs: [2][3][4]

All three of the HOT-x drugs produce psychedelic effects according to Shulgin.[1][2] The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act as prodrugs to these compounds.[2]

Interactions

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See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

See also

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References

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  1. ^ a b c d e f Shulgin, A.; Manning, T.; Daley, P.F. (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley: Transform Press. ISBN 978-0-9630096-3-0.
  2. ^ a b c d e f g h Alexander T. Shulgin; Ann Shulgin (1991). PiHKAL: A Chemical Love Story (1st ed.). Berkeley, CA: Transform Press. ISBN 978-0-9630096-0-9. OCLC 25627628.
  3. ^ Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
  4. ^ Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 792–792. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
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